B. Ahuja, A. Sudalai
Jan 15, 2015
Citations
0
Influential Citations
13
Citations
Journal
Tetrahedron-asymmetry
Abstract
Abstract An efficient approach to (2S,3S)-3-hydroxypipecolic acid with an overall yield of 10.2% and 98% ee starting from 1,5-pentanediol has been developed. The key steps employed in the synthesis are the d -proline catalyzed sequential α-aminooxylation/Horner–Wadsworth–Emmons olefination of an aldehyde and the Pd-catalyzed MOM-ether directed aza-Claisen rearrangement of an allylic trichloroacetimidate.