Yunyun Liu, Xuwen Chen
Jul 1, 2018
Citations
0
Influential Citations
6
Citations
Journal
Tetrahedron
Abstract
Abstract The Cu(OAc)2-catalyzed three-component reactions of o-aminophenols, acyl chlorides and 1,2-dichloroethane (DCE) have been established for the efficient synthesis of 3,4-dihydro-2H-benzo[b][1,4]oxazines (3,4-dihydro-1,4-benzoxazines). This method features advantages of the one-pot operation enabling N-acylation, C Cl bond amidation and etherification, as well as the structural divergence of the synthesized products.