M. Chrzanowska, Agnieszka Grajewska, Zofia Meissner
Apr 8, 2012
Citations
0
Influential Citations
18
Citations
Journal
Tetrahedron
Abstract
A sequence of two reactions: the Petasis reaction, in which an aminoacetaldehyde acetal was used as the amine component, followed by Pomeranz–Fritsch–Bobbitt cyclization, has been shown to be a convenient and simple method for the synthesis of tetrahydroisoquinoline-1-carboxylic acids. Using this method several acids have been prepared in good to excellent yields and characterized as hydrochloride salts.