Masahito Yoshida, Koya Saito, Yuta Fujino
May 27, 2014
Citations
0
Influential Citations
22
Citations
Journal
Tetrahedron
Abstract
Abstract A concise and step-economical total synthesis of biologically active frutinones has been achieved. Tributylphosphine (PBu 3 ) efficiently induced the tandem acyl transfer-cyclization of carbonates 5 to afford 3-methoxycarbonylflavone derivatives 4 in excellent yields. Finally, concomitant deprotection and lactonization under acidic conditions furnished the desired frutinones A ( 1a ), B ( 1b ), and the proposed structure of frutinone C ( 1c ).