Yunxiang Chen, Yangwei Huang, Xu-yang Zhao
Jan 13, 2015
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0
Influential Citations
4
Citations
Journal
Synthetic Communications
Abstract
Abstract A concise process of 1,3-diacetoxy-2-[2′-(2″,4″-difluorophenyl)prop-2′-en-1′-yl]propane has been developed. Diethyl malonate was C-alkylated with 2,3-dichloropropene and then the ester groups were reduced by LiAlH4, followed by acylation to provide 2-(2′-chloroprop-2′-en-1′-yl)-1,3-diacetoxypropane. The chloropropene was finally coupled with 2,4-difluorophenylmagnesium bromide and catalyzed by Fe(acac)3 to afford the title compound in good total yield. GRAPHICAL ABSTRACT