M. Toyota, Chiyo Komori, Masataka Ihara
Sep 28, 2000
Citations
1
Influential Citations
113
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Journal
The Journal of organic chemistry
Abstract
A six-step formal total synthesis of a natural alkaloid, mappicine (3), has been achieved. The highlight of our synthetic strategy is an intramolecular hetero Diels-Alder reaction that was used for the construction of the CD ring system of mappicine (3). In addition, it was demonstrated that the Sonogashira coupling reaction of 2-chloro-3-hydroxymethylquinoline (8c) with trimethylsilylacetylene proceeded at room temperature in excellent yield.