Ya-Ru Gao, Shi‐Huan Guo, Zhuan Zhang
Nov 27, 2013
Citations
1
Influential Citations
13
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Serinolamide A, isolated from a species of marine cyanobacteria, exhibits a moderate agonist effect and selectivity for the CB1 cannabinoid receptor, which is unusual for marine natural products. Herein, we reported a highly efficient enantiospecific first total synthesis of (+)-serinolamide A from l -serine in nine steps with 30% overall yield. The synthesis method provides a facile, practicable, and economical approach for the preparation of other similar endocanabinoid lipids.