W. Noland, A. Novikov, Christopher D. Brown
Oct 7, 2019
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Journal
Synthetic Communications
Abstract
Abstract 2-Methylindole condenses with acetophenones under acidic conditions to produce 2-arylanilines in moderate to good yields. The reaction proceeds well with a range of 3′- and 4′- substituted acetophenones (fluoro-, chloro-, bromo-, iodo-, methyl, methoxy), and select 2′- substituted ones (fluoro-, methoxy-). No products were obtained with nitro- substitution in any position. GRAPHICAL ABSTRACT