A. W. Noltes, F. Kögl
Sep 2, 2010
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Journal
Recueil des Travaux Chimiques des Pays-Bas
Abstract
The ethyl hemiacetal of ethyl glyoxylate (ethyl ethoxy-hydroxyacetate, I) has been found to undergo thermal condensation with various ketones. The new reaction presents a simple method of attaching a hydroxyacetic ester side chain to a carbon atom adjacent to the carbonyl function, giving 2-hydroxy-4-keto-alkanoic esters. Of several transformations to which these esters are readily accessible the dehydration reaction in particular has been investigated.