A. Harutyunyan
Jun 1, 2016
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Journal
Russian Journal of Organic Chemistry
Abstract
It is known that pyrido[1,2-a]pyrimidine derivatives exhibit a broad spectrum of biological activity such as antibacterial, fungicidal, antiviral, antitumor, anti-monoamine oxidase, etc. [1–3]. Syntheses on the basis of 2-chloro-4-oxo-4H-pyrido[1,2-a]pyrimidine3-carbaldehyde leading to the corresponding 3-(diarylmethyl) derivatives and pentacyclic tetraaza heterocycle were described previously [4, 5]. In continuation of studies on the synthesis of pyridopyrimidine derivatives, the present communication reports the condensation of 2-hydroxy-4H-pyrido[1,2-a]pyrimidin-4-one (1) [6] with 4-nitrobenzaldehyde (2a), 2-chloroquinoline-3-carbaldehyde (2b), and 2-hydroxynaphthalene-1-carbaldehyde (2c). The reactions were carried out at a 1-to-2 molar ratio of 2 : 1 in boiling glacial acetic acid in the presence of a catalytic amount of sulfuric acid.