Kang-chien Liu, B. Shih, J. Chern
Jul 1, 1988
Citations
0
Influential Citations
9
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
Treating 2-mercaptobenzohydrazide (1a) with cyanogen bromide gave 3-amino-2-imino-3,4-dihydro-2.H-1,3-benzothiazin-4-one (2a). This compound underwent further cyclocondensation with a second molecule of cyanogen bromide or S-methylisothiourea sulfate to afford the biologically interesting 2-amino-1,2,4-triazolo-[5,1-b][1,3]benzothiazin-9-one (3c). Compound 3c could also be prepared directly from 1a by treating with excess amount of cyanogen bromide in more satisfactory yield.