E. Oishi, A. Yamada, E. Hayashi
Jul 25, 1987
Citations
0
Influential Citations
6
Citations
Journal
Chemical & Pharmaceutical Bulletin
Abstract
The reaction of 7-(methylsulfonyl)-1-phenyl-1H-1,2,3-triazolo[4,5-d]pyridazine (1) with active methylene compounds or ketones (3a-g) in the presence of sodium hydride gave the corresponding 7-substituted 1-phenyl-1H-1,2,3-triazolo[4,5-d]pyridazines (4a-g). A [4 + 2] cycloaddition occurred in the reaction with enamines or ynamines (9a-d) to give the corresponding arenotriazoles (10a-d). Similarly, the reaction of 7-chloro1 -phenyl-1H-1,2,3-triazolo[4,5-d]pyridazine (2) with 3 and 9 resulted in the formation of 4 and arenotriazoles (12), respectively.