H. Reichel
1976
Citations
0
Influential Citations
3
Citations
Journal
Current Medical Research and Opinion
Abstract
SummaryThe author reviews the experimental evidence relating to the activity of orally administered parasympatholytic drugs and comments that the effectiveness, especially of those with spasmolytic activity, can only be judged if allowance is made for the physiological and pharmacodynamic conditions at the target site.Using hyoscine-N-butylbromide as an example it has been shown that, apart from a local effect on the gut wall, therapeutic effects on muscular organs are possible and even at very low blood levels, below the limit of detection in the systemic circulation, if the site of action has a special affinity for the drug. The absence of anticholinergic side-effects and low rates of absorption into the blood cannot disprove the effects of drugs which are accumulated at the site of action. The combination of specific binding capacity and reactivity of the smooth musculature to hyoscine-N-butylbromide is to be regarded as the optimum condition for a specific therapeutic action. Opposite conclusions are ...