A. Siva Lakshmi Devi, Y. Srinivasa Rao, Y. Suresh
May 1, 2007
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Journal
Magnetic Resonance in Chemistry
Abstract
We report the complete 1H and 13C NMR assignment of impurities of six Lopinavir (2S)‐N‐[(2S, 4S, 5S)‐5‐{[2‐(2,6‐dimethylphenoxy)acetyl]amino}‐4‐hydroxy‐1,6‐diphenyl hexan‐2‐yl]‐3‐methyl‐2‐(2‐oxo‐1,3‐diazinan‐1‐yl)butan‐ amide. Two of the impurities are regioisomers and GCOSY used to differentiate the two structures. The spectral assignments for all six impurities were achieved by concerted application of one and two‐dimensional NMR techniques (1H NMR, 13C NMR, DEPT, GCOSY, GHSQC and GHMBC). Copyright © 2007 John Wiley & Sons, Ltd.