M. Sundaralingam, J. Abola
Feb 23, 1972
Citations
0
Influential Citations
20
Citations
Journal
Nature: New biology
Abstract
ADENOSINE 3′,5′-monophosphate (cyclic AMP) plays a role in many metabolic and genetic processes1. To modify the biological activity of the natural metabolite, various analogues have been synthesized and studied2. For example, the N(6) alkyl analogues possess not only greater but more specific biological activity1 and the isosteric phosphonate analogue, where the 5′ oxygen atom is substituted by a methylene group also possesses biological activity (ref. 2 and J. G. Moffat, private communication). The crystal structure determination of the latter was undertaken to compare its stereochemistry with that of the natural compound, cyclic AMP3.