A. Bozzoli, E. Marotta, S. Piani
Jun 4, 1993
Citations
0
Influential Citations
1
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Several 3-O-derivatives of (2S,3S)-5-(2-dimethylaminoethyl)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one, the parent compound of diltiazem, have been prepared and the M/P conformation ratios have been determined by 1H NMR spectroscopy in solution, at room temperature. In general, the (M,2S,3S) conformer is the major component; however, a preference for the (P,2S,3S) conformation has been observed for the first time in the 3-silyloxy derivatives.