J. Lavayre, M. Ptak, M. Leng
Aug 18, 1975
Citations
0
Influential Citations
6
Citations
Journal
Biochemical and biophysical research communications
Abstract
Summary C(8) substituted adenosine 5′-monophosphates were prepared by the reaction of C(8)bromo-AMP with α-ω diaminoalkyl (or α aminoalkyl). These products were characterized by circular dichroism and nuclear magnetic resonance. It is shown that the conformation of these nucleotides depends upon the length and the nature of the substituents. In addition, the preparation and some properties of a fluorescent derivative (the conjugate of 8(2-aminoethyl)amino-AMP and fluorescamine) is reported.