T. Siahaan, S. Chakrabarti, D. V. Vander Velde
Sep 16, 1992
Citations
0
Influential Citations
9
Citations
Journal
Biochemical and biophysical research communications
Abstract
Cyclo(1,5)-Ac-Pen-Arg-Gly-Asp-Cys-NH2 (3) is a potent inhibitor of platelet aggregation. Nuclear magnetic resonance (NMR) and restrained molecular dynamics were used to study the conformations of 3. Elucidation of RGD conformations in 3 will increase the understanding of interaction between the RGD-sequence with GPIIb/IIIa.