Y. Aubin, G. Audran, H. Monti*
Sep 1, 2006
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Abstract
This paper describes the racemic and stereoselective synthesis of novel conformationally locked 3'-methyl-2',3'-oxiranefused carbocyclic nucleosides (nucleosides numbering). The key step is the direct coupling of an alcohol bearing the 1-methyl-6-oxabicyclo[3.1.0]hexane scaffold with diversely substituted purine nucleobases under Mitsunobu reaction conditions providing only the N 9 target molecules.