Oleksiy S. Artamonov, T. Bulda, T. Fam
Dec 1, 2015
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Influential Citations
2
Citations
Journal
Heterocyclic Communications
Abstract
Abstract A stereolibrary of conformationally restricted oxazole-containing amino acids, namely all isomers of 5–pyrrolydinyl- and 5-piperidinyloxazole-4-carboxylic acids, were designed and synthesized in three steps by the reaction of the corresponding N-Boc-protected amino acids and ethyl isocyanoacetate. These natural products-inspired amino acids are valuable building blocks for the synthesis of peptidomimetics and potential lead compounds for drug discovery.