S. Bentley, D. J. Milner
Mar 23, 1993
Citations
0
Influential Citations
9
Citations
Journal
Journal of Organometallic Chemistry
Abstract
Abstract Nitrobenzenes bearing masked aldehyde, ketone and ketoester functions at the 4-position undergo conjugate addition with Grignard reagents in THF at − 15°C. Sequential treatment of the 4-substituted nitrobenzenes with primary or secondary alkyl magnesium halides followed by 2,3-dichloro-5,6-dicyano-1,4-benzoquinone affords the corresponding 2-alkylated derivatives in 50–80% yields.