Ying-Rui Wu, Jing-feng Zhao, Jingbo Chen
Feb 5, 2009
Citations
0
Influential Citations
35
Citations
Journal
Organic letters
Abstract
A highly flexible and concise total synthesis of (+)-podophyllotoxin featured with an enantioselective sequential conjugate addition-allylation reaction was reported. Starting from commercially available 3,4,5-trimethoxycinnamic acid, this new route leads to (+)-podophyllotoxin 1 in only eight steps with 29% overall yield.