Alfredo R. M. Oliveira, J. A. Villar, F. Simonelli
Feb 19, 2007
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Influential Citations
8
Citations
Journal
Tetrahedron Letters
Abstract
In this letter we present a new 2,4,4-trimethyl-2-oxazoline anion-zinc derivative that has a remarkable thermal stability when compared with the corresponding cyanocuprate counterpart. The yields from conjugated addition to several 2-nitrovinyl benzenes are moderate to good and the reaction itself is easier to execute and cleaner. As an application, this methodology was applied to an alternative synthesis of (±)-Rolipram, a drug with several interesting biological activities.