A. Catalano, A. Carocci, F. Corbo
Nov 1, 2008
Citations
0
Influential Citations
31
Citations
Journal
European journal of medicinal chemistry
Abstract
1-Benzyl-N-(2,6-dimethylphenyl)piperidine-3-carboxamide and 4-benzyl-N-(2,6-dimethylphenyl)piperazine-2-carboxamide, two conformationally restricted analogues of tocainide, were designed and synthesized as voltage-gated skeletal muscle sodium channel blockers. They showed, with respect to tocainide, a marked increase in both potency and use-dependent block.