J. Pons, J. Fauchère, F. Lamaty
May 1, 1998
Citations
1
Influential Citations
26
Citations
Journal
European Journal of Organic Chemistry
Abstract
As a new scaffold for peptidomimetic synthesis, a highly constrained bifunctional diketopiperazine, 4, has been prepared by smooth N-alkylation with tert-butyl bromoacetate. As a first application, we describe herein the synthesis of new peptidomimetics of the Arg-Gly-Asp (RGD) sequence. The product 30, which shows a selective platelet-aggregation inhibiting activity, can be used as a lead for the preparation of more potent products.