Hanbyeol Jo, Ahmed H. Hassan, Seung-Young Jung
Jan 30, 2018
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0
Influential Citations
24
Citations
Journal
Organic letters
Abstract
A concise synthesis of 8-azabicyclo[3.2.1]octanes via sequential oxidative Mannich reactions is described. This approach involves an intermolecular oxidative Mannich coupling reaction between N-aryl pyrrolidines with TMS enol ether and a subsequent intramolecular oxidative Mannich cyclization of the corresponding silyl enol ether. DDQ is used as a key oxidant for both reactions.