Wulin Yang, Fei-Fei Tang, F. He
Sep 24, 2015
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Influential Citations
42
Citations
Journal
Organic letters
Abstract
A highly efficient asymmetric 1,3-dipolar cycloaddition of azomethine ylides to 5-alkylidene thia(oxa)zolidine-2,4-diones catalyzed by a chiral N,O-ligand/Cu(CH3CN)4BF4 system is reported, affording structurally novel spirocyclic pyrrolidine-thia(oxa)zolidinediones with a spiro-heteroquaternary stereogenic center in good to excellent yields (up to 99%), with excellent levels of diastereo- and enantioselectivity (dr up to 99:1; ee up to 98%).