M. Elchisak, R. Polinsky, M. Ebert
Dec 4, 1978
Citations
1
Influential Citations
40
Citations
Quality indicators
Journal
Life sciences
Abstract
Abstract Homovanillic acid (HVA) labelled with two deuterium atoms (d2-HVA) was used to determine the contribution of HVA in the blood to HVA in the urine and CSF of monkeys. During and after a six-hour intravenous infusion of d2-HVA at a constant rate, the levels of both d2-HVA and endogenous HVA (d0-HVA) in plasma, urine, and CSF were determined by gas chromatography-mass spectrometry, and the relative enrichments of d2-HVA in each of these fluids calculated. Results indicate that HVA in the urine is derived exclusively from the blood, with no contribution from renal metabolism of dopamine (DA). Furthermore, less than one percent of HVA in either lumbar or ventricular CSF is derived from circulating HVA. The plasma elimination curve of d2-HVA was biexponential, with a terminal phase half-life ( t 1 2 ) of 44 minutes and an apparent volume of distribution of 0.8 liters/kg.