M. Sohail, F. Tanaka
Nov 19, 2019
Citations
0
Influential Citations
7
Citations
Journal
Chemistry
Abstract
Control of chemical reactions is necessary for obtaining designer chemical transformation products and for preventing decompositions and isomerizations of compounds of interest. For the control of chemical events in aqueous solutions, the use of aqueous buffers is a common practice. However, no molecules that buffer non-aqueous solutions were commonly used. Here we demonstrate that 1,3-cyclohexanedione derivatives have buffering functions in non-aqueous solutions. We also show that these molecules can be utilized to alter and control chemical reactions. 1,3-Cyclohexanedione derivatives inhibited both acid-catalyzed and base-catalyzed isomerizations and decompositions in organic solvents. The reaction products obtained in the presence of the buffering molecule 2-methyl-1,3-cyclohexanedione differed from those obtained in the absence of the buffering molecule. The use of buffering molecules that work in organic solvents provides a strategy to control chemical reactions and expands the range of compounds that can be synthesized.