Y. Kawai, Kousuke Takanobe, A. Ohno
1995
Citations
0
Influential Citations
18
Citations
Journal
Bulletin of the Chemical Society of Japan
Abstract
Stereoselectivity of microbe-catalyzed reduction of ethyl 2-methyl-3-oxobutanoate to optically active 3-hydroxy-2-methylbutanoate can be controlled by the addition of methyl vinyl ketone to the reaction system. The reduction by Geotrichum candidum, Endmyces magnusii, and Mucor javanicus with an appropriate additive affords the corresponding anti-(2S,3S)-hydroxy ester selectively, whereas the reduction by bakers’ yeast and Candidatropicalis with an additive gives the corresponding syn-(2R,3S)-hydroxy ester selectively.