Xinfeng Tao, Yangwei Deng, Zhi-quan Shen
Sep 10, 2014
Citations
0
Influential Citations
62
Citations
Journal
Macromolecules
Abstract
N-substituted glycine N-thiocarboxyanhydrides (NTAs) are alternative monomers to prepare polypeptoids with large-scale producing potential compared to the corresponding N-carboxyanhydrides (NCAs) due to their easily synthetic approach and stability during purification and storage. Novel monomer N-butylglycine NTA (NBG-NTA) has been synthesized and well characterized for the first time. Rare earth borohydrides [RE(BH4)3(THF)3, RE = Sc, Y, La, Nd, Dy, and Lu] have been first applied in the polymerization of sarcosine NTA (Sar-NTA) and NBG-NTA to achieve high molecular weight (MW) hydrophilic and hydrophobic polypeptoids. Polysarcosines (PSars), poly(N-butylglycine)s (PNBGs), and their copolymers with high yields, high MWs, and moderate MW distributions are synthesized at 60 °C by using RE(BH4)3(THF)3 initiators. MWs of polypeptoids are controlled by feed molar ratios. For instance, PSar with an absolute Mn of 27.7 kDa (DP = 390) and PDI of 1.14 is produced successfully from Sar-NTA. Thermoresponsive random ...