Faustine Dubar, C. Slomianny, J. Khalife
Jul 22, 2013
Citations
0
Influential Citations
79
Citations
Quality indicators
Journal
Angewandte Chemie
Abstract
Metal health: Ferroquine is a ferrocene-based analogue of the antimalarial drug chloroquine. In addition to the primary mechanism of quinoline action, fluorescent probe studies in infected red blood cells show another mechanism is at work. It is based on the production of HO(·) in the acidic and oxidizing environment of the digestive vacuole of the malaria parasite and implies that, with ferroquine, reinvasion can be inhibited.