Kishore Karumanchi, S. Natarajan, Sunil Gadde
Dec 20, 2019
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Chemical Papers
Abstract
A convenient, safe and cost-effective method for carrying out the key vinylation of 5-ethoxy-2-pyrrolidinone ( 8 ) in the preparation of 5-vinyl-2-pyrrolidinone ( 2 ) in the presence of potassium carbonate is described. This present procedure is developed by replacing inherently hazardous ethyl magnesium bromide with inexpensive and eco-friendly potassium carbonate. The reaction was performed on a multi-gram scale, with vinyl magnesium bromide as the vinylation reagent, in an 81% yield to give the 5-vinyl-2-pyrrolidinone with excellent purity and without the need for chromatography.