Wha Chen, M. Cava
1987
Citations
0
Influential Citations
28
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Bromination of pyrrole by 1,3-dibromo-5,5-dimethylhydantoin, followed by direct reaction with BOC anhydride and DMAP, affords the stable N-BOC dervatives of 2-bromopyrrole and 2,5-dibromopyrrole. Lithium-halogen exchange of the latter with n-butyllithium generates the N-BOC derivatives of 2-lithiopyrrole, 2,5-dilithiopyrrole or 5-bromo-2-lithiopyrrole, which react with various electrophiles to give substituted N-BOC pyrroles in excellent yield.