Li Ming, Wang Shuwen, Wen Lirong
Jul 1, 2005
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Influential Citations
19
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Journal
Journal of Heterocyclic Chemistry
Abstract
Twelve new 7-aryl-3-cyanopyrazolo[1,5-a]pyrimidines (3a-f) and ethyl 7-arylpyrazolo[1,5-a]pyrimidine-3-carboxylates (3g-l) have been conveniently synthesized by the reaction of enaminones with 5-amino-1H-pyrazoles in good yields under microwave irradiation. With one substituded enaminone, only one regioiso-mer was obtained. The structures of new compounds were fully confirmed by elemental analysis, ir, 1H nmr and X-ray diffraction (XRD) analysis. A plausible reaction mechanism for the synthesis of title compounds is presented. The antifungal activities of some compounds are also reported.