Dennis A. Parrish, Z. Zou, C. Leigh Allen
Dec 19, 2005
Citations
1
Influential Citations
20
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Treatment of amines with 1-(4-nitrophenol)- N -( O -benzylhydroxy)carbamate yields the O -benzyl protected N -hydroxyureas. Hydrogenation of the O -benzyl protected N -hydroxyureas over 5% Pd/BaSO 4 cleanly gives the N -hydroxyureas in good yield. In addition to primary and secondary aliphatic and aromatic amines, this method converts amino sugars to the corresponding N -hydroxyureas without extensive protecting group chemistry.