H. Sheibani, K. Saidi, M. Abbasnejad
Sep 1, 2016
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0
Influential Citations
14
Citations
Journal
Arabian Journal of Chemistry
Abstract
Abstract A general and easy method for the synthesis of 4,6-disubstituted-3-cyano-2(1 H )-iminopyridine or 3-amino-6-chloro-1-aryl-1 H -benzo[ h ]chromen-2-yl cyanide derivatives in the presence of high surface area MgO as a highly effective heterogeneous base catalyst is described. These compounds were synthesized using one-pot multicomponent reactions of the properly substituted acetophenone, appropriate aldehyde, ammonium acetate and malononitrile or three component reactions of 4-chloro-2-naphthol, aldehydes and malononitrile, respectively, in DMF. The compound of 7c was evaluated for its anxiolytic activities.