P. W. Woo
Oct 1, 1988
Citations
0
Influential Citations
5
Citations
Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
Reaction of 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose (3) with [14C]cyanotrimethylsilane, generated insitu by reaction of potassium [14C]cyanide and chlorotrimethylsilane in the presence of sodium iodide and 2,6-lutidine, gave 2,5-anhydro-3,4,6-tri-O-benzoyl-D-[1-14C]allononitrile (4). Sequential reaction of the latter with hydrogen selenide, ethyl bromopyruvate, and methanolic sodium methoxide gave methyl β-D-ribofuranosyl-4-[2-14C]selenazolcarboxylate (7), penultimate precursor to [2-14C]CI-935, or 2-β-D-ribofuranosyl-4-[2-14C]selenazolecarboxamide (8).