H. Stark
Sep 1, 2000
Citations
0
Influential Citations
5
Citations
Journal
Archiv der Pharmazie
Abstract
Cyclopropyl 4‐(3‐(1H‐imidazol‐4‐yl)propyloxy)phenyl methanone (ciproxifan) is a novel reference antagonist for the histamine H3 receptor. Despite the former Mitsunobu reaction the actual key reaction for preparation based on SNAr for acylated fluoroaromatics with an additional cyclization in a one‐pot procedure needs no chromatographic purification steps and results in good yields.