S. Tekale, S. B. Munde, Sushama S. Kauthale
May 4, 2018
Citations
0
Influential Citations
9
Citations
Journal
Organic Preparations and Procedures International
Abstract
Quinazolinones have a unique position in pharmaceutical and medicinal chemistry due their diversified biological activities. Quinazolinone derivatives act as the building blocks of more than 150 natural products and many commercially marketed drugs, including Cloroqualone, Afloqualone, and Quinethazone. Cloroqualone is a drug with sedative and antitussive properties. Afloqualone is a muscle-relaxant and Quinethazone is widely used in the treatment of hypertension. Besides this, quinazolinones are well recognized for antibacterial, antifungal, cytotoxic, anticancer, anti-inflammatory, antimalarial, anticonvulsant, antidepressant, antioxidant, activities. On account of their therapeutic potential and wide spectrum of biological activities, quinazolinones have attracted the attention of medicinal and synthetic organic chemists. The development of new synthetic strategies for the synthesis of quinazolinones is thus of considerable interest. A literature survey reveals that the synthesis of quinazolinones can be achieved by the reaction of isatoic anhydride, ammonium acetate or amine and aldehyde using catalysts and reagents such as thiamine hydrochloride, b-cyclodextrin, Cu(NO3)2.3H2O, 14 L-Proline, Preyssler nanoparticles, sulfonated porous carbon, silica supported zinc (II) chloride, 2,4,6-trichloro[1,3,5]triazine, acetic acid, ionic liquids 21 and ultrasound irradiation. Solvent-free or solid state reactions reduce environmental pollution and lower handling costs due to their operational simplicity and ease of work up procedures. These reactions can be performed by using the reactants alone or using clays, silica, alumina or other catalytic materials. Multicomponent reactions under solvent-free conditions constitute an important tool for efficient functional group transformations.