R. Olivera, R. SanMartin, E. Domínguez
Sep 13, 2000
Citations
0
Influential Citations
35
Citations
Journal
The Journal of organic chemistry
Abstract
A series of new 1,2-bis(o-haloaryl)ethanones is efficiently prepared and applied to the synthesis of 4,5-bis(o-haloaryl)isoxazoles. Isolation of intermediate hydroxyisoxazolines, which are structurally examined, provides a definitive proof for a heterocyclization mechanism based on an amine exchange process. The isolation and X-ray crystallographic studies of significant side products such as benzamides and triarylpropionitriles are also described.