A. N. Voldeng, J. Fifer, D. R. Brown
Apr 1, 1979
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0
Influential Citations
1
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ, 1) has been utilized as a coupling reagent to attach sterically unhindered acids to the potassium salt of 6-aminopenicillanic acid (4) at room temperature. The excellent yields and rapidity of the reaction illustrate the convenience of utilizing 1 as the coupling reagent to directly prepare the potassium salt of certain penicillins.