Y. Elossaily
Mar 15, 2007
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Influential Citations
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Journal
Phosphorus, Sulfur, and Silicon and the Related Elements
Abstract
3-Cyano-5-oxo-4(2-thienyl)-indeno[1,2-b]pyridin-2-[1H]thione 3 was prepared from indanone 1 with arylidene cyanoacetamide or from arylideneindanone 2 with cyanoacetamide. S-Alkylation of 3 with halogenated compounds afforded compounds 4a–h . Compounds 4d–h underwent ring closure with sodium ethoxide to produce indenothienopyridines 5 a–e , respectively. Treatment of 3 using ethylchoroacetate or chloroacetone gave compounds 6 and 7 , respectively. Compounds 5a and 5d were reacted with carbon disulphide in pyridine to give compounds 8a and 8b . Most of the synthesized compounds were screened in vitro for their antimicrobial activities against four species of bacteria and six species of fungi using Chloramphenicol (5%) and Terbinafine (5%) as a standard.