Zhao-xia Guo, A. Cammidge, D. Horwell
Aug 1, 2000
Citations
0
Influential Citations
31
Citations
Journal
Synthetic Communications
Abstract
Abstract Aromatic, aliphatic and sterically hindered amines react smoothly with commercially available N, N'-bis-BOC-S-methylisothiourea 2 in the presence of mercury chloride to give the protected guanidine in good yield. It is particularly noteworthy that 2 can also be employed in a straightforward, two-step synthesis of monoaryl internal guanidines.