S. Srivastava, A. Nema, S. Srivastava
Apr 1, 2008
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0
Influential Citations
3
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Journal
ChemInform
Abstract
Carbazole on reaction with chloroacetyl chloride afford N9-(chloroacetyl)-carbazole, 1 which on treatment with hydrazine hydrate has yielded N9-(hydrazinoacetyl)-carbazole, 2. Condensation of 2 with various aromatic aldehydes afforded N 9 -(arylidene hydrazinoacetyl)-carbazoles, 3 which on cycloaddition with chloroacetyl chloride in the presence of triethylamine yielded N 9 -[hydrazinoacetyl-(2-oxo-3-chloro-4-substituted aryl azeitidine)]-carbazoles 4. All the above reactions are also performed by microwave assisted synthetic method. The structures of all the products are characterized by microanalytical data and spectroscopic techniques. All the synthesized products are screened for their antibacterial activity against Bacillus subtilis. Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus and antifungal activity against Aspergillus nigar, Aspergilus flavus, Fusarium oxisporium and Trichoderma viride.