Tracy M. M. Maiden, N. Mbelesi, P. Procopiou
Jun 6, 2018
Citations
0
Influential Citations
1
Citations
Journal
Organic & biomolecular chemistry
Abstract
We report a modular five step synthetic route to the febrifugines that employs 2-(chloromethyl)allyl-trimethylsilane as a conjunctive reagent for the coupling of the piperidine and quinazolinone groups. We also demonstrate the application of a recent Rh-catalyzed quinazolinone synthesis for the facile generation of febrifugine analogs.