N. Sudarshan, N. Narendra, H. Hemantha
Nov 14, 2007
Citations
0
Influential Citations
16
Citations
Journal
The Journal of organic chemistry
Abstract
Reaction of 96% formic acid with isocyanates derived from N-Fmoc alpha-amino acids/peptide acids catalyzed by DMAP has yielded a new class of stable formamides as crystalline solids which have been characterized by IR, 1H NMR, 13C NMR, and mass spectroscopy. Conversion of the side chain carboxylic acid of N-Fmoc-5-oxazolidinones of Asp/Glu into the N-formyl group also has been accomplished. The reaction is simple, mild, and high yielding.