V. I. Pol'shakov, G. G. Dvoryantseva, Y. Sheinker
Aug 1, 1984
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Journal
Pharmaceutical Chemistry Journal
Abstract
Prospidin-3,12-bis(2'-hydroxy-3'-ehloropropyl)-3,12-diaza-6,9-diazoniadispiro [5.2.5.2] hexadecanedichloride (I) -is an antineoplastic d~ug used in the treatment of a number of forms of malignant neoplasms [4, 6]. For a study of the mechanism of the antineoplastic action of I and possible pathways of its metabolism, data on the structure of products of its chemical conversions, associated with functional changes in the terminal cytotoxic groups, are of great importance.