W. M. Featherston
Nov 8, 1952
Citations
0
Influential Citations
5
Citations
Quality indicators
Journal
Journal of the American Medical Association
Abstract
Asterol® dihydrochloride (2-dimethylamino-6-[beta-diethylaminoethoxy]-benzothiazole dihydrochloride) is one of a group of compounds, the benzothiazoles, that have been reported to have antifungal activity. 1 The purpose of this paper is to report a case of convulsions occurring in an infant treated with this chemical in an ointment base. It has been reported as being a primary irritant locally when applied in a 10% concentration. 2 In a search of the literature no reports were found referring to this compound as a central nervous system irritant. REPORT OF A CASE J. J., aged 4 months, had a normal neonatal period. The mother was Rh o negative and the father was Rh o positive. There was no unusual jaundice. The blood count remained normal. Feedings were of breast milk, supplemented occasionally by artificial feeding. At 3½ months of age, the weight was 15 lb. 6 oz. (6.97 kg.). At the three month examination there