Xiaoping Zhan, Sijing Chen, Guochun Tang
May 1, 2007
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Journal
Polymers for Advanced Technologies
Abstract
The main objective of this present study was to synthesize a new type of copolymer membrane that presented a linear release property in clonidine transdermal drug delivery system. Three monomers, 2-hydroxy-3-phenoxypropylacrylate, 4-hydroxybutyl acrylate, and isobutyl methacrylate were treated under strong power UV radiation to prepare a new type of copolymer membrane. The effects of monomers' ratios, membrane thickness, and clonidine concentration on the permeation rates were investigated. It was discovered that the membrane controlled clonidine near zero-order release. Furthermore, the membrane was characterized by FTIR, DSC, and SEM. Copyright © 2007 John Wiley & Sons, Ltd.